Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp
详细信息 查看全文
- 作者：Juan Lia ; Lingli Huanga ; Xu Wanga ; Yuanhu Pana ; Zhaoying Liub ; Dongmei Chena ; Yanfei Taoa ; Qinghua Wua ; c ; Zonghui Yuana ; yuan5802@mail.hzau.edu.cn" class="auth_mail
- 关键词：QCT (Q0) ; quinocetone ; Q1 ; 1-desoxyquinocetone ; Q2 ; dideoxyquinocetone ; Q3 ; carbonyl-reduced metabolites of 1-deoxyquinocetone ; Q4 ; carbonyl- and double-bond-reduced metabolites of 1-deoxyquinocetone ; Q5 ; carbonyl-reduced metabolites of dideoxyquinocetone ; Q6 ; phenyl ring hydroxylation metabolites of carbonyl-reduced quinocetone ; Q7 ; carbonyl-reduced quinocetone ; Q8 ; double-bond-reduced metabolite of 4-deoxyquinocetone ; Q9 ; phenyl ring hydroxylation metabolites of quinocetone ; OLA ; olaquindox ; C
- 刊名：Food and Chemical Toxicology
- 出版年：July 2014
- 年：2014
- 卷：69
- 期：Complete
- 页码：109-119
- 全文大小：1838 K
文摘
- •
Fecal excretion is the major route of quinocetone elimination.
- •
N–O and carbonyl group reduction are the main pathways of quinocetone metabolism.
- •
Liver and kidney are exposed to significant amounts of QCT and its metabolites.
- •
Quinocetone toxicity depends on the clearance route of this drug.