Absence of Non-histone Protein Complexes at Natural Chromosomal Pause Sites Results in Reduced Replication Pausing in Aging Yeast Cells
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- 作者：Marleny Cabral1 ; Xin Cheng1 ; Sukhwinder Singh2 ; Andreas S. Ivessa1 ; 3 ; ivessaan@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：chromosomal DNA ; aging ; replicative aging ; DNA damage ; baker's yeast ; chromosomal fragile sites ; non-histone protein complexes ; DNA replication
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 November 2016
- 年：2016
- 卷：17
- 期：7
- 页码：1747-1754
- 全文大小：2484 K
文摘
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Reduced replication pausing at fragile sites in aging and caloric-restricted cells
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Age-dependent reduction in pausing is independent of Rrm3 and Sir2
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Fragile sites-bound proteins are cytosolic in aged and caloric-restricted cells
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Findings may have implications to understand chromosome rearrangements during aging