Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity
Novel aldose reductase inhibitors exhibiting antioxidant activity were designed and synthesized based on quinoxalin-2(1H)-one scaffold. Phenolic hydroxyl containing compounds 6b and 6f exhibited not only significant ALR2 inhibition and selectivity but also antioxidant properties. Structure-activity relationship and docking studies further confirmed the importance of phenolic hydroxyl for enhancing ALR2 inhibitory activity and adding an antioxidant property.