Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat
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- 作者：Bauer ; Inge ; Vollmar ; Brigitte ; Jaeschke ; Hartmut ; Rensing ; Hauke ; Kraemer ; Thomas ; Larsen ; Reinhard ; et. al.
- 关键词：Cytokine-induced neutrophil chemoattractant-1 ; Intercellular adhesion molecule-1 ; Intravital microscopy ; Liver ; Microcirculation ; Neutrophil ; Nuclear factor κ ; B
- 刊名：Journal of Hepatology
- 出版年：2000
- 出版时间：September, 2000
- 年：2000
- 卷：33
- 期：3
- 页码：395-406
- 全文大小：1.56 M
文摘
Background/Aim: Glutathione depletion contributes to acetaminophen hepatotoxicity and is known to induce the oxidative stress reactant heme oxygenase-1. The metabolites of the heme oxygenase pathway, biliverdin, carbon monoxide, and iron may modulate acetaminophen toxicity. The aim of this study was to assess cell-type specific expression of heme oxygenase-1 and its impact on liver injury and microcirculatory disturbances in a model of acetaminophen-induced hepatitis.