Signaling in Sperm: More Different than Similar

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• 作者：U.B. Kaupp¹ ; ^{u.b.kaupp@caesar.de} ; T. Strü ; nker²
• 关键词：microswimmer ; calcium ; cyclic nucleotides ; protons ; ion channels
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：101-109
• 全文大小：2041 K
• 卷排序：27

文摘

For a given sensory cell type, signaling motifs are rather uniform across phyla. By contrast, sperm from different species use diverse repertoires of sperm-specific signaling molecules and even closely related protein isoforms feature different properties and serve different functions. This surprising diversity has consequences for strategies in fertilization research and it will take some time to get the big picture. We discuss the function of receptors, ion channels, and exchangers embedded in cellular pathways from different sperm species.