Regional brain volumes changes in adult male FMR1-KO mouse on the FVB strain
详细信息 查看全文
- 作者：J.K.Y. Laia ; jon.lai@yorku.ca" class="auth_mail" title="E-mail the corresponding author ; laijky@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; J.P. Lerchb ; jason@phenogenomics.ca" class="auth_mail" title="E-mail the corresponding author ; L.C. Doeringc ; doering@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; J.A. Fostera ; jfoster@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author ; J. Ellegoodb ; jacob@mouseimaging.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ASD ; autism spectrum disorder ; B6 ; C57Bl/6 ; DTI ; diffusion tensor imaging ; FMR1 ; Fragile X Mental Retardation 1 gene ; FMRP ; Fragile X Mental Retardation Protein ; FXS ; Fragile X Syndrome ; KO ; knock-out ; MRI ; magnetic resonance imaging ; PBS ; phosphate-buffered saline ; PFA ; paraformaldehyde
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：24 March 2016
- 年：2016
- 卷：318
- 期：Complete
- 页码：12-21
- 全文大小：614 K
文摘
- •
We examined brain volume differences in FMR1-KO mice compared to WT FVB using structural MRI.
- •
We observe changes in white matter and in regions related to the frontal-striatal circuitry.
- •
Changes in FMR1-KO-FVB mouse better reflect the clinical phenotype compared to the FMR1-KO-B6 mouse.