Associations Between Neurocognitive Impairment and Biomarkers of Poor Physiologic Reserve in a Clinic-Based Sample of Older Adults Living with HIV

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• 作者：Kalvin C. Yu ; MDAuthor Vitae ; Paul A. D'Avanzo ; MSAuthor Vitae ; Leigh Nesheiwat ; MDAuthor Vitae ; Richard E. Greene ; MDAuthor Vitae ; Antonio Urbina ; MDAuthor Vitae ; Perry N. Halkitis ; PhD ; MS ; MPHAuthor Vitae ; Farzana Kapadia ; PhD ; MPH ; ^{farzana.kapadia@nyu.edu}Author Vitae
• 关键词：HIV ; neurocognitive impairment ; screening
• 刊名：Journal of the Association of Nurses in AIDS Care
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：28
• 期：1
• 页码：55-66
• 全文大小：245 K
• 卷排序：28

文摘

Data from a cross-sectional study of a clinic-based sample of older people living with HIV (PLWH; n = 100) were used to examine associations between biomarkers of physical health and neurocognitive impairment (NCI). In this sample, anemia, chronic kidney disease (CKD) stages 4-5, and hypocalcemia were associated with impairment in executive functioning or processing speed. Furthermore, participants with anemia were more likely to have CD4+ T cell counts <200 cells/mm3 (χ2 [1] = 19.57, p < .001); hypocalcemia (χ2 [1] = 17.55, p < .001); and CKD 4-5 (χ2 [2] = 10.12, p = .006). Black and Hispanic participants were more likely to be anemic compared to other races and ethnicities (χ2 [3] = 12.76, p = .005). Common medical conditions (e.g., anemia, hypocalcemia, CKD) should be investigated as potential contributors to NCI in older PLWH. Additionally, laboratory testing in racial/ethnic minority PLWH may help inform NCI screening.