Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures
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- 作者：Erika Kaguea ; 1 ; ekague@ib.usp.br" class="auth_mail" title="E-mail the corresponding author ; Paula Roya ; 2 ; Garrett Asselinb ; Gui Hua ; Jacqueline Simoneta ; Alexandra Stanleyc ; Craig Albertsonb ; Shannon Fishera ; 3 ; shanfish@bu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osterix/Sp7 ; Craniofacial skeleton ; Sutures ; Osteogenesis ; Zebrafish mutant
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：413
- 期：2
- 页码：160-172
- 全文大小：4854 K
文摘
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Zebrafish lacking Sp7 make bone, consistent with the human mutant phenotype.
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Global gene expression correlates with delayed osteogenesis and poor mineralization.
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The mutant skull has specific defects in shape and bones of the cranial vault.
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Signaling from mature bone limits osteoblast recruitment during skull growth.