Fractionated stereotactic radiotherapy for acoustic neuromas: A prospective monocenter study of about 158 cases

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• 作者：Fabien Litre^a ; ^{flitre@chu-reims.fr} ; Pascal Rousseaux^a ; Nicolas Jovenin^b ; Arnaud Bazin^a ; Philippe Peruzzi^a ; Didier Wdowczyk^c ; Philippe Colin^c
• 关键词：Radiotherapy ; Fractioned stereotactic radiotherapy ; Acoustic neuroma
• 刊名：Radiotherapy and Oncology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：106
• 期：2
• 页码：169-174
• 全文大小：710 K

文摘

Purpose

To evaluate long-term outcomes and efficacy of fractionated stereotactic radiotherapy in the treatment of acoustic neuromas.

Material and methods

Between January 1996 and December 2009, 158 acoustic neuromas were treated by FSR in 155 patients. They received a dose of 50.4 Gy, with a safety margin of 1-2 mm with a median tumor volume at 2.45 mL (range: 0.17-12.5 mL) and a median follow-up duration at 60 months (range: 24-192).

Results

FSR was well tolerated in all patients with mild sequelae consisting in radiation-induced trigeminal nerve impairments (3.2 % ), Grade 2 facial neuropathies (2.5 % ), new or aggravated tinnitus (2.1 % ) and VP shunting (2.5 % ). The treatment failed in four patients (2.5 % ) who had subsequent surgery respectively at 20, 38, 45 and 84 months post-FSR. The local tumor control rates were respectively 99.3 % , 97.5 % and 95.2 % at 3, 5 and >7-year of follow-up. For initial Gardner-Robertson Grade 1 and 2 ANs, the preservation of useful hearing was possible in 54 % of the cases; only Grade 1 ANs had stabilized during the course of the follow-up with 71 % >7 years. However, hearing preservation was not correlated to the initial Koos Stage and to the radiation dose delivered to the cochlea. Tinnitus (70 % ), vertigo (59 % ), imbalance (46 % ) and ear mastoid pain (43 % ) had greatly improved post-FRS in most patients. Tumor control, hearing preservation and FRS toxicity were quite similar in patients with NF2, cystic acoustic neuroma, prior surgical resection and Koos Stage 4 AN. No secondary tumors were observed.

Conclusion

FSR is a safe and effective therapeutic for acoustic neuromas and could be an alternative to microsurgery. Compared to radiosurgery, there are no contraindications for fractioned doses of stereotactic radiotherapy especially for Stage-4 tumors and patients at high risk of hearing loss.