Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?
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- 作者：Subodh Kumara ; P. Hemachandra Reddya ; b ; c ; d ; e ; f ; hemachandra.reddy@ttuhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR or miRNA ; microRNA ; AD ; Alzheimer's disease ; MCI ; mild cognitive impairment ; CSF ; cerebral spinal fluid ; ECF ; extracellular fluid ; AUC ; area under curve ; ROC ; receiver operating characteristic ; mRNA ; messenger RNA ; RISC ; RNA-induced silencing complex ; HDL ; high-density lipoprotein ; MV ; microvesicle ; HCC ; hepatocellular carcinoma ; PD ; Parkinson's disease ; ALS ; amyotrophic lateral sclerosis ; HD ; Huntington's disease ; BMC ; blood mononuclear cell ; NINDCs ; non-inflammatory neurological disease co
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1617-1627
- 全文大小：965 K
文摘
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Micro RNAs play a key role in cellular processes, including development, cell proliferation and replicative senescence.
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Circulatory micro RNAs are promising peripheral biomarkers for human diseases and aging.
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Circulatory micro RNAs can be found in bodily fluids, including blood products serum/ plasma, CSF, ECF, saliva and urine.
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Micro RNAs are strong indicators of disease progression and pathogenesis of Alzheimer’s disease.