Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism
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- 作者：Jiang ; Shun-Yuan ; Shyu ; Rong-Yaun ; Yeh ; Ming-Yang ; Jordan ; V. Craig
- 关键词：Antiestrogen ; Estrogen ; Estrogen receptor ; Growth regulation ; Hepatoma ; Tamoxifen
- 刊名：Journal of Hepatology
- 出版年：1995
- 出版时间：December, 1995
- 年：1995
- 卷：23
- 期：6
- 页码：712-719
- 全文大小：1.00 M
文摘
Background/Aims: Tamoxifen has previously been shown to prolong the survival of patients with advanced stages of hepatocellular carcinoma and it has been suggested that it inhibits the growth of hepatoma cells through an estrogen receptor-dependent mechanism. We have studied the effects of the synthetic estrogen, mestranol, and the antiestrogen, tamoxifen, on the growth regulation of hepatoma cells in vitro.