Oral Nitazoxanide caused high mortality in acute T.cruzi infection in mice. High dose nitazoxanide didn't cause mortality nor tissues damage in healthy mice. Both, parasitemia and tissue damage were higher in nitazoxanide treated animals. Parasitemia and tissues damage are directly related to nitazoxanide dose. Nifurtimox and nitozaxonide combination was less effective than nifurtimox only.