Effet de l'hexachlorobenzène sur certains paramètres de la fonction de reproduction mâle chez Meriones unguiculatus

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• 作者：Lotfi Bitri ; Wafa Darragi ; Latifa Ouertani ; Daniel Maurel ; Moncef Ben Saad
• 关键词：Meriones ; Toxicity ; Testes ; Hexachlorobenzene (HCB) ; Testosterone
• 刊名：Comptes Rendus Biologies
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：331
• 期：5
• 页码：380-388
• 全文大小：800 K

文摘

Organochlorine pesticides are known to cause disturbances in many physiological functions. The effects of in vivo administered hexachlorobenzene (HCB) on the male testicular function were studied in Meriones unguiculatus. Three groups of sexually mature meriones were orally exposed to 1.6, 4, and 16 mg/kg of body weight in olive oil for 30 days. Morphological and morphometrical estimations were applied to quantify some structural constituents of the testes. Testicular weight was significantly decreased in all treated groups, while no change was noted in seminal vesicle weight. A decrease in the spermatozoid content of the seminiferous tube was noted and appeared correlated with a modification of the process of spermatogenesis. Spermatic activity in HCB-treated animals testes decreased significantly, particularly in the group treated with the higher dose (href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml9&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=13aef3cd76adf1fd2565d78f59c112e6"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">60±3.16 %  vs. href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml10&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=6cc3022f529ba991f5f40b64bab921ce"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">88±4.89 % in controls). Plasma testosterone levels were decreased significantly in the groups treated with 4 and 16 mg[HCB]/kg BW (href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml11&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=363c4ad1898daeed026b923b2702d15f"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">0.48±0.08 ng/ml and href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml12&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=e493dfe48f903a2811375b4b33274eca"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">0.54±0.07 ng/ml) comparatively to controls (href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml13&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=590c66dea2f663301e561613ecf22782"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">1.08±0.1 ng/ml) href=""/science?_ob=MathURL&_method=retrieve&_udi=B6X1F-4S69H7V-1&_mathId=mml14&_user=1067359&_cdi=7241&_rdoc=8&_acct=C000050221&_version=1&_userid=10&md5=ec946d8cdb1f236db7e3ffc4ac627d4c"" title=""Click to view the MathML source"" alt=""Click to view the MathML source"">p<0.01. To cite this article: L. Bitri et al., C. R. Biologies 331 (2008).