Identification of stable and reactive metabolite(s) of nelfinavir in human liver microsomes and rCYP3A4
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- 作者：Shalu Jhajra1 ; Saranjit Singh ; ssingh@niper.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nelfinavir ; HLM ; CYP3A4 ; Diquinone metabolite ; N-Oxide metabolite
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：214-227
- 全文大小：1143 K
文摘
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Structures of major and trace level stable and reactive metabolites of nelfinavir were characterized using LC–MS tools.
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A total of thirty nine stable metabolites were detected.
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ortho-Diquinone and N-oxide metabolites were also detected, which are known to be reactive in nature. But these metabolites did not show any interaction with nucleophiles, possibly due to steric hindrance at the site of interface.