Booster vaccination of adults with reduced-antigen-content diphtheria, Tetanus and pertussis vaccine: Immunogenicity 5 years post-vaccination

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• 作者：Peter B. McIntyre ; Margaret A. Burgess ; Annemarie Egan ; Lode Schuerman ; Bernard Hoet
• 关键词：Antibody persistence ; Diphtheria ; Tetanus ; Pertussis ; Adult
• 刊名：Vaccine
• 出版年：2009
• 出版时间：11 February 2009
• 年：2009
• 卷：27
• 期：7
• 页码：1062-1066
• 全文大小：355 K

文摘

At 60 months post-vaccination, adults (mean age 45.6 years) randomised to receive combined reduced-antigen-content diphtheria–tetanus and acellular pertussis vaccine (dTpa) versus tetanus–diphtheria (Td) + monovalent acellular pertussis (pa) were seroprotected against diphtheria (≥0.016 IU/mL Vero cell assay) and tetanus (≥0.1 IU/mL ELISA assay) in 94.4 % and 96.2 % , respectively (dTpa), compared with 93.7 % and 90.6 % (Td + pa). Anti-FHA, anti-PT and anti-PRN antibodies (≥5 EL.U/mL) were maintained in 100 % , 89.5 % and 95.0 % of dTpa versus 100 % , 85.5 % and 90.6 % of pa vaccine recipients. At 5 years post boosting, antibody levels to diphtheria and tetanus are similar amongst adults receiving a dTpa or dT, and pertussis antibodies remain above pre-booster levels in at least 85 % .