Roux-en-Y gastric bypass augments the feeding responses evoked by gastrin-releasing peptides

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• 作者：Martha C. Washington ; MS^a ; Thaer R. Mhalhal ; BVSc^a ; Tanisha Johnson-Rouse ; MS^b ; Jose Berger ; PhD^b ; John Heath ; PhD^a ; Randy Seeley ; PhD^b ; Ayman I. Sayegh ; DVM ; MS ; PhD^a ; ^{sayeghai@mytu.tuskegee.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：GRP ; Roux-en-Y ; Food intake ; Celiac artery ; Cranial mesenteric artery
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：206
• 期：2
• 页码：517-524
• 全文大小：1131 K

文摘

Roux-en-Y gastric bypass (RYGB) is the most effective method for the treatment of obesity, and metabolic disease RYGB may reduce body weight by altering the feeding responses evoked by the short-term satiety peptides.

Materials and methods

Here, we measured meal size (MS, chow), intermeal interval (IMI) length, and satiety ratio (SR, IMI/MS; food consumed per a unit of time) by the small and the large forms of gastrin-releasing peptide (GRP) in rats, GRP-10 and GRP-29 (0, 0.1, 0.5 nmol/kg) infused in the celiac artery (CA, supplies stomach and upper duodenum) and the cranial mesenteric artery (CMA, supplies small and large intestine) in an RYGB rat model.

Results

GRP-10 reduced MS, prolonged the IMI, and increased the SR only in the RYGB group, whereas GRP-29 evoked these responses by both routes and in both groups.

Conclusions

The RYGB procedure augments the feeding responses evoked by exogenous GRP, possibly by decreasing total food intake, increasing latency to the first meal, decreasing number of meals or altering the sites of action regulating MS and IMI length by the two peptides.