HIV-1 Tat: coping with negative elongation factors

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• 作者：Garber ; Mitchell E ; Jones ; Katherine A
• 关键词：CDK9 cyclin dependent kinase 9 ; CTD carboxy-terminal domain ; CycT1 cyclin T1 ; DRB5 ; 6-dichloro-1-β ; -D-ribofuranosylbenzimidazole ; DSIF DRB-sensitivity-inducing factor ; ELF elongation factor ; FCP1TFIIF-interacting CTD phosphatase 1 ; NELF negative ELF co
• 刊名：Current Opinion in Immunology
• 出版年：1999
• 出版时间：August, 1999
• 年：1999
• 卷：11
• 期：4
• 页码：460-465
• 全文大小：596 K

文摘

The intrinsic processivity of RNA polymerase II complexes arises from a complex interplay between the recently identified positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF (5,6-dichloro-1-β-D-ribofuranosylbenzimidazole [DRB]-sensitivity-inducing factor) and the negative elongation factor complex (NELF). Elements in nascent HIV-1 RNA function in concert with these factors and the HIV-1 Tat protein to ensure that viral transcription is induced strongly in activated T cells. Studies in the past year have elucidated key aspects of the Tat trans-activation mechanism that help to define this important paradigm for RNA-mediated control of transcription elongation.