The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X₇ receptor in the dorsal root ganglia

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• 作者：Jinyan Xie^a ; ^e ; ¹ ; Shuangmei Liu^a ; ¹ ; Bing Wu^a ; ¹ ; Guilin Li^a ; Shenqiang Rao^a ; Lifang Zou^a ; Zhihua Yi^a ; Chunping Zhang^a ; Tianyu Jia^a ; Shanhong Zhao^a ; Gü ; nther Schmalzing^b ; Ralf Hausmann^b ; Hong Nie^c ; Guodong Li^a ; ^d ; Shangdong Liang^a ; ^{liangsd@hotmail.com}
• 关键词：P2X7 receptor ; Dorsal root ganglia ; Satellite glial cell ; Resveratrol ; Neuropathic pain
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：24-35
• 全文大小：2300 K
• 卷排序：103

文摘

Activated P2X7 receptor in DRG SGC aggravated pain in CCI rats. Upregulation of P2X7 and GFAP, cytokines in DRG was increased after CCI. RES inhibited BzATP-activated currents in DRG non-neurons in CCI rats. RES inhibited upregulated P2X7 and GFAP, cytokines in DRG. RES relieved hyperalgesia mediated by P2X7 in DRG SGCs of CCI rats.