This study is to unravel the function of PKCɛ in SP cells of renal cell carcinoma.
Knockdown of PKCε suppresses SP cell sorting in the 769P cell line.
Knockdown of PKCε suppresses cancer stem cell phenotype of 769P SP cells.
PKCε suppresses 769P SP cell sorting by negatively activating ABCB1 transporter.
PKCε regulates stemness of 769P SP cells via PI3K/Akt and MAPK/ERK pathways.