Association between the variable number of tandem repeat polymorphism in the third exon of the dopamine D₄ receptor gene and sensitivity to analgesics and pain in patients undergoing painful cosmetic surgery

详细信息    查看全文

• 作者：Yoshinori Aoki^a ; ^b ; ^{aoki-ys@igakuken.or.jp} ; Daisuke Nishizawa^a ; ^{nishizawa-ds@igakuken.or.jp} ; Shinya Kasai^a ; ^{kasai-sy@igakuken.or.jp} ; Ken-ichi Fukuda^b ; ^{kfukuda@tdc.ac.jp} ; Tatsuya Ichinohe^c ; ^{ichinohe@tdc.ac.jp} ; Shuichiro Yamashita^d ; ^{syamashita@tdc.ac.jp} ; Kazutaka Ikeda^a ; ^{ikeda-kz@igakuken.or.jp}
• 关键词：Dopamine D4 receptor ; Japanese ; Opioid ; PCA ; Postoperative pain ; VNTR
• 刊名：Neuroscience Letters
• 出版年：2013
• 出版时间：10 May, 2013
• 年：2013
• 卷：542
• 期：Complete
• 页码：1-4
• 全文大小：251 K

文摘

To elucidate the mechanisms of individual differences in pain and analgesic sensitivity, we analyzed the variable number of tandem repeat polymorphism in the third exon of the dopamine D₄ receptor gene. Alleles that were less than four repeats long and four or more repeats long were considered Short and Long, respectively. We found that the Short/Short genotype group was significantly more sensitive to pain and less sensitive to analgesics than the Short/Long + Long/Long genotype group. Our data suggest that this polymorphism may predict individual differences in pain and analgesic sensitivity and help achieve adequate pain control in the future.