Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats
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- 作者：Xing-Hua Yuea ; b ; Jia-Qing Tonga ; Zhao-Jun Wanga ; Jun Zhanga ; Xu Liub ; Xiao-Jie Liuc ; Hong-Yan Caia ; Jin-Shun Qia ; jinshunqi2009@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DU-14 ; Amyloid β protein ; Dehydroepiandrosterone sulfate ; Spatial memory ; Theta rhythm ; Long term potentiation ; Synaptic plasticity
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：83-92
- 全文大小：2194 K
文摘
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The neuroprotective action of steroid sulfatase inhibitor DU-14 was investigated.
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DU-14 attenuated Aβ-induced cognitive deficits in spatial learning and memory of rats in Morris water maze test.
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DU-14 prevented Aβ-induced decrease in theta rhythm of hippocampal local field potential in the CA1 region.
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DU-14 protected hippocampal synaptic plasticity against Aβ-induced suppression of long term potentiation.
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DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity.