Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression
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- 作者：Rodrigo Machado Pereiraa ; Guilherme Á ; lvaro Ferreira-Silvaa ; Marcos Pivattob ; Luciana de Á ; vila Santosc ; Vanderlan da Silva Bolzanic ; Daniela Aparecida Chagas de Paulad ; Jaqueline Carvalho de Oliveirae ; Clá ; udio Viegas Jú ; niorf ; Marisa Iontaa ; marisaionta@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; Cell cycle arrest ; (&minus ; )-Cassine ; (&minus ; )-Spectaline ; Piperidine alkaloids ; Senna spectabilis
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：86-92
- 全文大小：1005 K
文摘
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(−)-Cassine/(−)-Spectaline alkaloid mixture inhibits cell proliferation in hepatocellular carcinoma cell line.
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Antiproliferative activity of (−)-cassine/(−)-spectaline alkaloids is associated to cell cycle arrest in G1/S transition.
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(−)-Cassine/(−)-Spectaline alkaloids are effective in modulating cyclin D expression.
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ERK activation is inhibited in HepG2 cells treated with (−)-cassine/(−)-spectaline alkaloids.