Short-term amiodarone treatment for atrial fibrillation after catheter ablation induces a transient thyroid dysfunction: Results from the placebo-controlled, randomized AMIO-CAT trial
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- 作者：Sø ; ren Zö ; ga Diederichsena ; 1 ; Soeren.Zoega.Diederichsen@regionh.dk" class="auth_mail" title="E-mail the corresponding author ; Stine Darknera ; 1 ; Xu Chena ; Arne Johannesenb ; Steen Pehrsona ; Jim Hansenb ; Ulla Feldt-Rasmussenc ; Jesper Hastrup Svendsena ; d ; e
- 关键词：Amiodarone ; Thyroid function tests ; Randomized controlled trial ; Atrial fibrillation
- 刊名：European Journal of Internal Medicine
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：36-41
- 全文大小：592 K
文摘
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No clinical adverse effects on the thyroid were seen in patients taking amiodarone.
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Amiodarone was associated with increased TSH, T4 and fT4, and decreased T3 and fT3.
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In the amiodarone group, 16% had biochemical hypothyroidism after 1 month.
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Thyroid dysfunction had decreased significantly 1 month after drug discontinuation.
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After 4 months, there were no differences from baseline.