Characterization of melanocortin receptors from stingray Dasyatis akajei, a cartilaginous fish
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- 作者：Akiyoshi Takahashia ; akiyoshi@kitasato-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Perry Davisb ; Christina Reinickb ; Kanta Mizusawaa ; Tatsuya Sakamotoc ; Robert M. Doresb
- 关键词：Adrenocorticotropic hormone (ACTH) ; Cartilaginous fish ; Melanocyte-stimulating hormone (MSH) ; Melanocortin receptor (MC receptor) ; Pituitary-interrenal axis ; Stingray (Dasyatis akajei)
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：232
- 期：Complete
- 页码：115-124
- 全文大小：1537 K
文摘
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Stingray expressed five subtypes of MCR gene as in teleost and tetrapod species.
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Stingray interrenal tissues expressed mc2r and mc5r as major MCR genes.
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Desacetyl-α-MSH produced cAMP with similar potency to ACTH on MC1R and MC2R.
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Desacetyl-α-MSH were equipotent to or slightly greater than ACTH on MC3R, 4R, and 5R.
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MC2R did not require coexpression with a MRAP1 cDNA for functional expression.