Administration of sulfosuccinimidyl-4-[N-maleimidomethyl] cyclohexane-1-carboxylate conjugated GP10025-33 peptide-coupled spleen cells effectively mounts antigen-specific immune response against mouse melanoma
详细信息 查看全文
- 作者：Xiaoli Changa ; Chang-Qing Xiaa ; b ; cqx65@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunotherapy ; Melanoma ; Peptide coupling ; Splenocytes ; SMCC
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：46-52
- 全文大小：1215 K
文摘
- •
Infusion of GP10025–33-coupled spleen cells leads to potent anti-melanoma immunity.
- •
GP10025–33-coupled spleen cell treatment induces antigen-specific IFN-γ-producing CD8 T cells.
- •
This approach takes advantage of homing nature of immune cells.