Brain MRI findings in 33 patients with mitochondrial disorders were reviewed.
Patients were grouped into those with mutations in mitochondrial DNA, SURF1 & POLG1.
Patients with mitochondrial mutations had more atrophic changes, cortical lesions and basal ganglia mineralization
All SURF1 patients had Leighs syndrome. No consistent pattern emerged in the POLG1 group.
The study confirms the heterogenous MRI findings in mitochondrial disorders.