Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study
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- 作者：Zili Zhanga ; 1 ; Jian Wanga ; 1 ; Jianxing Hea ; 1 ; Xiansheng Zengb ; 1 ; Xindong Chenc ; 1 ; Mingmei Xionga ; Qipeng Zhoua ; Meihua Guoa ; Defu Lia ; Wenju Lua ; d ; wlu92@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SNP ; single nucleotide polymorphism ; OR ; odds ratio ; CI ; confidence interval ; MAF ; minor allele frequency ; LD ; linkage disequilibrium ; HWE ; Hardy-Weinberg equilibrium ; SOCCs ; Store-operated Ca2 ; + channels ; SOCE ; Store-operated Ca2 ; + entry channels ; ROCCs ; receptor-operated Ca2 ; + channels ; tagSNPs ; tagging single nucleotide polymorphisms
- 刊名：Meta Gene
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：9
- 期：Complete
- 页码：191-196
- 全文大小：270 K
文摘
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TRPC4 and TRPC7 associated with lung cancer risk in 4866 case-control
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Adverse effects of TRPCs variants estimated based on the pathway study
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Subjects carrying “≥ 1” variant alleles had a 1.29-fold risk, compared with “0”.
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Lung cancer risk increased with variant allele's number in a dose-response.