5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local ¦Â adrenoceptors

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• 作者：Maria Cl¨¢udia G. Oliveira-Fusaro ; Juliana Trindade Clemente-Napimoga ; Juliana Maia Teixeira ; Karla Elena Torres-Ch¨¢vez ; Carlos Am¨ªlcar Parada ; Cl¨¢udia Herrera Tambeli
• 关键词：Serotonin (5HT) ; Nociception ; Prostaglandins ; Norepinephrine ; Temporomandibular joint
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：102
• 期：3
• 页码：458-464
• 全文大小：670 K

文摘

The 5-hydroxytryptamine (serotonin, 5-HT) is an important inflammatory mediator found in high levels in the synovial fluid of the temporomandibular joint (TMJ) of patients with inflammatory pain. In this study, we used the nociceptive behavior responses, measured as flinching the head and rubbing the orofacial region, as a nociceptive assay. We demonstrated that the local blockade of the 5-HT₃ receptor and ¦Â₁ or ¦Â₂-adrenoceptors, the depletion of norepinephrine in the sympathetic terminals and the local inhibition of cyclooxygenase significantly reduced 5-HT-induced TMJ nociception. These results demonstrated that 5-HT induces nociception in the TMJ region by the activation of ¦Â₁ and ¦Â₂ adrenoceptors located in the TMJ region and local release of sympathetic amines and prostaglandins. Therefore, the high levels of 5-HT in the synovial fluid of patients with TMJ inflammatory pain may contribute to TMJ pain by similar mechanisms.