Methotrexate normalized keratinocyte activation cycle by overturning abnormal keratins as well as deregulated inflammatory mediators in psoriatic patients
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- 作者：Tamilselvi Elangoa ; tami24684@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Anand Thirupathib ; Swapna Subramanianc ; Haripriya Dayaland ; Pushpa Gnanaraje
- 关键词：MTX ; methotrexate ; K14 ; K10 ; K16 ; K17 ; keratin 14 ; 10 ; 16 ; 17 ; TNF-α ; tumor necrosis factor alpha ; IFN-γ ; interferon gamma ; TGF-β1 ; transforming growth factor beta1 ; KCs ; keratinocytes
- 刊名：Clinica Chimica Acta
- 出版年：2015
- 出版时间：7 December 2015
- 年：2015
- 卷：451
- 期：part_PB
- 页码：329-337
- 全文大小：1080 K
文摘
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This study shows the effect of MTX on normal keratin K14 and K10 in psoriasis.
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MTX treatment normalizes abnormal keratin K16, K17 in psoriasis.
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MTX increases the deactivation signal (TGF-β1) of keratinocyte activation cycle.
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Impact of MTX treatment on Keratinocyte Activation cycle in psoriasis.