Association of plasma and cortical amyloid beta is modulated by APOE 蔚4 status

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• 作者：Shanker Swaminathan ; Shannon L. Risacher ; Karmen K. Yoder ; John D. West ; Li Shen ; Sungeun Kim ; Mark Inlow ; Tatiana Foroud ; William J. Jagust ; Robert A. Koeppe ; Chester A. Mathis ; Leslie M. Shaw ; John Q. Trojanowski ; Holly Soares ; Paul S. Aisen ; Ronald C. Petersen ; Michael W. Weiner ; Andrew J. Saykin ; Alzheimer's Disease Neuroimaging Initiative
• 关键词：Alzheimer's disease ; Mild cognitive impairment ; Alzheimer's Disease Neuroimaging Initiative ; Amyloid beta ; Plasma amyloid beta ; Positron emission tomography ; Pittsburgh compound B ; Apolipoprotein E
• 刊名：Alzheimer's Dementia
• 出版年：January, 2014
• 年：2014
• 卷：10
• 期：1
• 页码：e9-e18
• 全文大小：679 K

文摘

Background

Apolipoprotein E (APOE) 蔚4 allele's role as a modulator of the relationship between soluble plasma amyloid beta (A尾) and fibrillar brain A尾 measured by Pittsburgh compound B positron emission tomography ([¹¹C]PiB PET) has not been assessed.

Methods

Ninety-six Alzheimer's Disease Neuroimaging Initiative participants with [¹¹C]PiB scans and plasma A尾_1-40 and A尾_1-42 measurements at the time of PET scanning were included. Regional and voxelwise analyses of [¹¹C]PiB data were used to determine the influence of APOE 蔚4 allele on association of plasma A尾_1-40, A尾_1-42, and A尾_1-40/A尾_1-42 with [¹¹C]PiB uptake.

Results

In APOE 蔚4鈭?but not 蔚4+ participants, positive relationships between plasma A尾_1-40/A尾_1-42 and [¹¹C]PiB uptake were observed. Modeling the interaction of APOE and plasma A尾_1-40/A尾_1-42 improved the explained variance in [¹¹C]PiB binding compared with using APOE and plasma A尾_1-40/A尾_1-42 as separate terms.

Conclusions

The results suggest that plasma A尾 is a potential Alzheimer's disease biomarker and highlight the importance of genetic variation in interpretation of plasma A尾 levels.