Prenatal, perinatal, and adolescent exposure to marijuana: Relationships with aggressive behavior

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• 作者：Olivier J. Barthelemy^a ; Mark A. Richardson^a ; ^b ; Howard J. Cabral^c ; Deborah A. Frank^d ; ^{dafrank@bu.edu}
• 关键词：THC ; delta-9-tetrahydrocannabinol ; CBCL ; Child Behavior Checklist ; TRF ; Achenbach Teacher Report Form ; YSR ; Achenbach Youth Self-Report
• 刊名：Neurotoxicology and Teratology
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：58
• 期：Complete
• 页码：60-77
• 全文大小：562 K
• 卷排序：58

文摘

This manuscript reviews animal research, as well as human research, on prenatal exposure and on marijuana use during adolescence. Potential psychosocial and psychopharmacological mechanisms are identified, as well as relevant confounds. The prenatal marijuana exposure literature provides minimal support for a direct relationship with aggressive behavior in childhood. The adolescent use literature suggests a marginal (at best) association between acute intoxication and aggressive behavior, and an association between chronic use and aggressive behavior heavily influenced by demographic variables, rather than direct, psychopharmacological mechanisms. Cannabis withdrawal symptoms also may include aggression and anger, but there is little evidence to suggest that these effects are large or specific to withdrawal from marijuana compared to other substances. This review offers recommendations for clinical care and public policy, as well as important questions for future research.