At least 43 epithermal Au, Au-Cu and Ag-Pb-Zn deposits occur in South China Block. Mineralization mainly occurred in two periods of 180–130 Ma and 120–90 Ma. Ore systems aged 180–130 Ma were formed in syn- to post-collision tectonic setting. The deposits aged 120–90 Ma resulted from the westward subduction of Pacific plate. South China Block collided with its surrounding continents since the end-Triassic.