Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro
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- 作者：Takeshi Takaradaa ; Noritaka Nakamichia ; Ryota Nakazatoa ; Takami Kakudab ; Hiroshi Kokuboa ; Shinsuke Ikenoa ; Saki Nakamuraa ; Nobuyuki Kuramotoc ; Eiichi Hinoia ; Yukio Yonedaa ; yyoneda@p.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Theanine ; Neural progenitors ; mTOR ; SLC38A1 ; Neurogenesis ; Glutamine
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：89-95
- 全文大小：2293 K
文摘
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Theanine promotes mTOR phosphorylation in neural progenitors.
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Theanine promotes the formation of embryonic and adult neurospheres.
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SLC38A1 overexpression promotes mTOR phosphorylation in pluripotent P19 cells.
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Theanine fails to further promote mTOR phosphorylation in SLC38A1 transfectants.
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Theanine promotes subsequent neuronal differentiation in embryonic progenitors.