文摘
The pharmacokinetic variability of ESL was extensive (25 fold). Based on TDM-data from the main laboratories in Norway, 71% of the patients using ESL was covered. The retention rate of ESL was 83%, 72% and 64% after 1, 2 and 3 years, respectively. Hyponatremia was observed in one third of the patients but less pronounced than with OXC.