Muscle-invasive bladder cancer is characterized by overexpression of thymidine kinase 1
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- 作者：Steffen Rausch ; M.D.a ; Joerg Hennenlotter ; B.Sc.a ; Katharina Teepe ; M.D.a ; Ursula Kuehsa ; Stefan Aufderklamm ; M.D.a ; Simone Bier ; M.D.a ; Johannes Mischinger ; M.D.a ; Georgios Gakis ; M.D.a ; Arnulf Stenzl ; M.D.a ; Christian Schwentner ; M.D.a ; Tilman Todenhö ; fer ; M.D.a ; b ; tilman.todenhoefer@med.uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder cancer ; Biomarker ; Thymidine kinase 1 ; Proliferation ; Molecular subtypes
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：33
- 期：10
- 页码：426.e21-426.e29
- 全文大小：1842 K
文摘
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The proliferation marker Thymidine Kinase 1 (TK1) is overexpressed in mucle-invasive bladder cancer (MIBC) compared to benign urothelium.
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The biological relevance of TK1 activity in MIBC is underlined by differential expression of TK1 mRNA in different subtypes of MIBC.
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In contrast to other cancer entities, the predictive capability of TK1 protein expression is limited in the present cohort of patients with MIBC.