Sam68 affects cell proliferation and apoptosis of human adult T-acute lymphoblastic leukemia cells via AKT/mTOR signal pathway
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- 作者：Qi Wang ; Yuanye Li ; Jingying Cheng ; Long Chen ; Hua Xu ; Qinghua Li ; Tianxiang Pang ; pang@ihcams.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sam68 ; T-cell acute lymphoblastic leukemia ; Proliferation ; Apoptosis ; AKT/mTOR signaling pathway
- 刊名：Leukemia Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：1-9
- 全文大小：2661 K
文摘
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Sam68 was upregulated in adult T-ALL patients’ samples and T cells.
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Sam68 knockdown impaired proliferation, induced apoptosis and cycle arrest in T-ALL cells.
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Sam68 knockdown downregulated CDK2, Bcl-xl and upregulated p21, Bad, cleaved caspase-9, caspase-3, PARP.
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Sam68 knockdown associated with changes in AKT/mTOR signaling pathway.
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Sam68 expression restoration reverted the above effects.