文摘
EE increased hippocampal neurogenesis, improving cognitive impairments and decreasing long-term seizure activity after TLE. These effects of EE might be mediated through SDF-1/CXCR4 pathway. AMD3100 reversed the effect of EE on neurogenesis, but it did not abolish the cognitive improvement induced by EE after TLE. EE combined with AMD3100 has the ability to suppress long-term seizure activity significantly.