Design, synthesis, biological evaluation and molecular docking study on peptidomimetic analogues of XK469
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- 作者：Qiao-Hong Xiaa ; 1 ; Wei Hub ; 1 ; Chen Lic ; Ji-Feng Wud ; Liang Yanga ; Xue-Mei Hana ; Yue-Mao Shena ; Zhi-Yu Lie ; Zh.Li@usciences.edu" class="auth_mail" title="E-mail the corresponding author ; Xun Lia ; tjulx2004@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：XK469 ; Quinoxaline peptidomimetic analogues ; Hydrophobic chain ; Topoisomerase II inhibitor ; Antineoplastic agents
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：311-325
- 全文大小：2626 K
文摘
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Quinoxaline peptidomimetic analogues derived from XK469 were proposed.
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These derivatives tend to have similar mechanism of action with XK469.
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Molecular docking studies provided visual evidences of binding modes of target compounds.
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Two compounds standed out from bioevaluation and might be promising leads.