Expression of Idh1R132H in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis
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- 作者：Chiara Bardella1 ; Osama Al-Dalahmah2 ; Daniel Krell1 ; Pijus Brazauskas3 ; Khalid Al-Qahtani4 ; Marketa Tomkova3 ; Julie Adam5 ; 6 ; Sé ; bastien Serres7 ; 8 ; Helen Lockstone9 ; Luke Freeman-Mills1 ; Inga Pfeffer4 ; Nicola Sibson7 ; Robert Goldin10 ; Benjamin Schuster-Bö ; eckler3 ; Patrick J. Pollard5 ; 11 ; Tomoyoshi Soga12 ; James S. McCullagh4 ; Christopher J. Schofield4 ; Paul Mulholland13 ; Olaf Ansorge14 ; Skirmantas Kriaucionis3 ; Peter J. Ratcliffe3 ; 5 ; Francis G. Szele2 ; francis.szele@dpag.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Ian Tomlinson1 ; 15 ; iant@well.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：30
- 期：4
- 页码：578-594
- 全文大小：8330 K
文摘
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Idh1R132H knockin in the mouse brain SVZ recapitulates features of gliomagenesis
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Self-renewal and proliferation of neural stem cells and progenitors increase
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SVZ cells proliferate ectopically, infiltrate the brain parenchyma, and form nodules
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Increases occur in 2HG levels, Wnt and telomere pathway activity, and DNA methylation