TRAF1 knockdown alleviates palmitate-induced insulin resistance in HepG2 cells through NF-魏B pathway
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- 作者：Wanlu Zhanga ; b ; 1 ; Zhuqi Tangc ; 1 ; Xiaohui Zhuc ; Nana Xiaa ; b ; Yun Zhaoa ; b ; Suxin Wanga ; b ; Shiwei Cuic ; neifenmicui@163.com" class="auth_mail" title="E-mail the corresponding author ; Cuifang Wangc ; binghuodinghuo@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRAF1 ; NF-魏B ; Inflammation ; Insulin resistance ; Type 2 diabetes
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：20 November 2015
- 年：2015
- 卷：467
- 期：3
- 页码：527-533
- 全文大小：2672 K
文摘
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TRAF1 accelerated PA-induced IR in HepG2 cells mediated through NF-魏B signaling.
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Knockdown of TRAF1 alleviated PA-induced IR in HepG2 cells.
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Knockdown of TRAF1 alleviated PA-induced lipid accumulation in HepG2 cells.
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Knockdown of TRAF1 reversed PA-induced suppression of glucose uptake in HepG2 cells.
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Knockdown of TRAF1 reversed PA-induced gluconeogenesis in HepG2 cells.