Association study of TRAF1/C5 polymorphism (rs10818488) with susceptibility to rheumatoid arthritis and systemic lupus erythematosus: A meta-analysis

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• 作者：Ke Xu¹ ; Hui Peng¹ ; Mo Zhou ; Wei Wang ; Rui Li ; Kao-Kao Zhu ; Min Zhang ; Peng-Fei Wen ; Hai-Feng Pan ; Dong-Qing Ye ; ^{ydq@ahmu.edu.cn}
• 关键词：RA ; rheumatoid arthritis ; SLE ; systemic lupus erythematous ; TNF ; tumor necrosis factor ; TRAF1/C5 ; tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 ; GWA ; genome-wide association ; HWE ; Hardy&ndash ; Weinberg equilibrium ; OR ; odd
• 刊名：Gene
• 出版年：2013
• 出版时间：15 March, 2013
• 年：2013
• 卷：517
• 期：1
• 页码：46-54
• 全文大小：597 K

文摘

To determine whether the tumor necrosis factor (TNF)-receptor associated factor 1/complement component 5 (TRAF1/C5) polymorphism (rs10818488) confers susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE), a meta-analysis was performed. A total of 11 studies with 17 comparisons (11 for RA, 6 for SLE) were available for this meta-analysis, which consisted of 13,456 patients, 12,259 controls for RA and 1,894 patients, 6,729 controls for SLE. A significant association of the A allele of TRAF1/C5 polymorphism (rs10818488) with RA susceptibility was detected in the North Africa population (OR = 1.557, 95 % CI: 1.225-1.977). Furthermore, the association between this allelic variant and SLE risk was additionally found in population of European (OR = 1.247, 95 % CI: 1.060-1.466). Analysis also showed the A/G allelic frequency of TRAF1/C5 variant (rs10818488), in different healthy populations, had a different distribution (¦Ö² = 269.41, P < 0.001). Taken together, our study demonstrates that the TRAF1/C5 polymorphism (rs10818488) may confer susceptibility to RA in North Africa population, and in European population, it might be a contributory factor towards SLE.