Caffeine alters glutamate-aspartate transporter function and expression in rat retina
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- 作者：Adriana Pinto de Freitasa ; dudadefreitas@ig.com.br" class="auth_mail" title="E-mail the corresponding author ; Danielle Dias Pinto Ferreiraa ; ferreiradanielle@id.uff.br" class="auth_mail" title="E-mail the corresponding author ; Arlete Fernandesa ; arletefernandes@id.uff.br" class="auth_mail" title="E-mail the corresponding author ; Robertta Silva Martinsa ; romartins@id.uff.br" class="auth_mail" title="E-mail the corresponding author ; Vladimir Pedro Peralva Borges-Martinsa ; vladimirppbm@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Matheus Figueiredo Sathlera ; msathler@id.uff.br" class="auth_mail" title="E-mail the corresponding author ; Maurí ; cio dos-Santos-Pereirab ; msp_biomed@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Roberto Paes-de-Carvalhoc ; robpaes@vm.uff.br" class="auth_mail" title="E-mail the corresponding author ; Elizabeth Giestal-de-Araujod ; egiestal@vm.uff.br" class="auth_mail" title="E-mail the corresponding author ; Ricardo Augusto de Melo Reise ; ramreis@biof.ufrj.br" class="auth_mail" title="E-mail the corresponding author ; Regina Celia Cussa Kubruslya ; kubrusly@vm.uff.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：cAMP ; cyclic adenosine monophosphate ; CNS ; central nervous system ; DPCPX ; 8-Cyclopentyl-1 ; 3-dipropylxanthine ; EAA ; excitatory amino acid ; EAAT ; excitatory amino acid transporter ; NMDA ; N-methyl-d-aspartate ; TTBS ; Tween 20 Tris-Buffered Saline
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：285-294
- 全文大小：1007 K
文摘
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l-Glutamate stimulates [3H]-d-Aspartate release more efficiently at PN3.
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Caffeine inhibits [3H]-d-Aspartate uptake in immature postnatal retina.
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l-Glutamate releases [3H]-d-Aspartate through transport reversal and NMDA receptors.
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A2AR antagonists decreases [3H]-d-Aspartate uptake.
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Caffeine induces [3H]-d-Aspartate release.