Association of PEAR1 genetic variants with platelet reactivity in response to dual antiplatelet therapy with aspirin and clopidogrel in the Chinese patient population after percutaneous coronary intervention
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- 作者：Yi Yao ; Xiao-fang Tang ; Jia-hui Zhang ; Chen He ; Yuan-liang Ma ; Jing-jing Xu ; Ying Song ; Ru Liu ; Xian-min Meng ; Lei Song ; Jue Chen ; Miao Wang ; Bo Xu ; Run-lin Gao ; Jin-qing Yuan ; dr_jinqingyuan@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CHD ; coronary heart disease ; ACS ; acute coronary syndrome ; ADP ; adenosine diphosphate ; PCI ; percutaneous coronary intervention ; HPR ; high platelet reactivity ; LPR ; low platelet reactivity ; PEAR1 ; platelet endothelial aggregation receptor 1 ; SNP ; single nucleotide polymorphisms ; TEG ; thromboelastography ; LDR ; ligase detection reaction ; LD ; loading dose ; BMI ; body mass index ; PLT ; platelet ; IPA ; inhibition of platelet aggregation ; DM ; diabetes mellitus ; ACEI ; angiotensin conversion enzyme inhibito
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：28-34
- 全文大小：360 K
文摘
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PEAR1 polymorphisms are related to ADP induced on-treatment platelet reactivity.
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Newly identified SNP rs57731889 of PEAR1 associated with low platelet reactivity.
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Changes at different sites of PEAR1 gene differentially affect platelet reactivity.