文摘
The anti-androgenic activity of five triazole fungicides was evaluated. No significant changes of anti-androgenic activity occur prior and after the metabolism. Tebuconazole, uniconazole, hexaconazole, penconazole, bitertanol potently inhibit CYP3A4. The anti-androgenic activity is highly correlated with the inhibition potency toward CYP3A4. Our study is helpful to the health risk assessment of triazole fungicides.