Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
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- 作者：Lisa L. Liu1 ; Johannes Landskron2 ; 3 ; Eivind H. Ask3 ; 4 ; Monika Enqvist1 ; Ebba Sohlberg1 ; James A. Traherne5 ; Quirin Hammer6 ; Jodie P. Goodridge3 ; 4 ; Stella Larsson7 ; Jyothi Jayaraman5 ; Vincent Y.S. Oei3 ; 4 ; Marie Schaffer1 ; Kjetil Taské ; n2 ; 3 ; 8 ; 9 ; 10 ; Hans-Gustaf Ljunggren1 ; Chiara Romagnani6 ; John Trowsdale5 ; Karl-Johan Malmberg1 ; 3 ; 4 ; 13 ; k.j.malmberg@medisin.uio.no" class="auth_mail" title="E-mail the corresponding author ; Vivien Bé ; ziat1 ; 11 ; 12 ; 13 ; vivien.beziat@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：15
- 期：5
- 页码：1088-1099
- 全文大小：4078 K
文摘
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NKG2C−/− donors have normal T cell immunity to cytomegalovirus
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NKG2C−/− donors have normal frequencies of adaptive NK cells
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CD2 is critical for antibody-triggered responses by adaptive NK cells
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CD2 synergizes with NKG2C in classical adaptive NK cells