The potential degradation feasibility for NB in US/nano metal oxide (series I and or series II)/H2O2 systems was measured by GC analysis at regular time intervals. Otherwise, some operational parameters such as ultrasonic irradiation time, solution pH value, H2O2 concentration, different weights of the nano-sized catalysts, NB concentration, leaching of the nano-sized catalysts, and reaction kinetics had been examined. It was found that H2O2 oxidant can effectively assist the sonocatalytic degradation of NB in the presence of nano-sized oxides (series I) and with more efficiency in the presence of nano-sized oxides (series II), and the effect of efficiency in degradation was changed in the order of (Fe2O3 > CuO > NiO > Co3O4). Therefore, oxides prepared in micellar solution were found to upgrade the economic aspect of NB degradation.