The full-length cDNA of grass carp ATF6 was cloned and identified.
CiATF6 was significantly up-regulated after stimulation with thermal stress.
In vitro, CiATF6 had high affinity with CiGRP78 and CiGRP94 promoters.
CiATF6 played a positive role in CiGRP78 and GRP94 transcription in CIK cells.