Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation

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• 作者：C. Sharma¹ ; N. Kumar² ; R. Pandey³ ; J.F. Meis⁴ ; ⁵ ; A. Chowdhary¹ ; ^{dranuradha@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Candida auris ; India ; multidrug resistant ; outbreak ; whole genome sequencing
• 刊名：New Microbes and New Infections
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：77-82
• 全文大小：366 K

文摘

Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).