Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

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• 作者：A.A. Roger Thompson¹ ; Allan Lawrie¹ ; ^{a.lawrie@sheffield.ac.uk}
• 关键词：pulmonary hypertension ; vascular remodeling ; BMPR2 ; miRNA ; hypoxia
• 刊名：Trends in Molecular Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：31-45
• 全文大小：2567 K
• 卷排序：23

文摘

Pulmonary arterial hypertension (PAH) describes a group of conditions with a common hemodynamic phenotype of increased pulmonary artery pressure, driven by progressive remodeling of small pulmonary arteries, leading to right heart failure and death. Vascular remodeling is the key pathological feature of PAH, but treatments targeting this process are lacking. In this review, we summarize important advances in our understanding of PAH pathogenesis from novel genetic and epigenetic factors, to cell metabolism and DNA damage. We show how these processes may integrate and highlight exploitable targets that could alter the relentless vascular remodeling in PAH.