The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2
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- 作者：Marianna Leonzino1 ; 2 ; Marta Busnelli1 ; Flavia Antonucci2 ; Claudia Verderio1 ; 3 ; Michele Mazzanti4 ; Bice Chini1 ; 3 ; b.chini@in.cnr.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 April 2016
- 年：2016
- 卷：15
- 期：1
- 页码：96-103
- 全文大小：2872 K
文摘
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Oxtr is necessary for the correct timing of the GABA switch in developing neurons
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Oxtr modulates the GABA switch by directly regulating the Cl− transporter KCC2
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OXT actions on KCC2 are restricted to an early and narrow time window
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Oxtr deficit causes long-lasting defects in excitation/inhibition balance in neurons